Documents
Bibliography
The Johns Hopkins ACG® System Bibliography provides links to more than 900 papers and reports from across the globe detailing various studies utilizing the ACG System in a variety of locations, populations, and innovative applications.
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ABSTRACT Introduction To investigate (1) prevalence and time trends in opioid use during pregnancy and (2) patterns of opioid use before and during pregnancy, among […]
Abstract Background Frailty is common amongst individuals presenting with acute ischaemic stroke (AIS). Not only has frailty been found to have disease-modifying effects in terms […]
Abstract Background & Aims Individuals with inflammatory bowel disease (IBD) may have worse obstetrical outcomes than those without IBD. We assessed the odds of severe […]
Abstract Background Family physicians (FP) are critical in providing outpatient end-of-life (EOL) care, yet most continuity measures do not consider temporal changes in visits. The […]
Abstract Background Many burn survivors experience poor long-term outcomes, including reduced quality of life and greater mortality than the general population, yet post-discharge interventions to […]
Abstract Introduction/Objectives: House call programs provide care for homebound patients. We conducted a case-control study to compare hospitalization and/or emergency department (ED) use by patients […]
Abstract Background Robotic-assisted total knee arthroplasty (rTKA) is being adopted rapidly, but data on its real-world safety compared with conventional TKA (cTKA) outside specialized centers […]
Abstract Objectives: To assess how social risk factors and socioeconomic status (SES) affect health care costs at a large, integrated health system of 45 clinics […]
Abstract Background While the short-term risks of severe injury among older adults (age≥65) are well studied, little is known about long-term functional outcomes in this […]
Purpose of review Health equity has emerged as a priority in urology, as disparities in access to care and health outcomes are driven by social, […]
Abstract Background Biennial breast screening enables timely diagnosis, a critical determinant of survival. However, this benefit depends on navigating complex healthcare systems where immigrant women […]
Abstract Background COVID-19 vaccines can cause rare but serious adverse events such as myocarditis and immune thrombocytopenia. Despite a lack of strong evidence, concerns have […]
Abstract Background Intensive end-of-life (EOL) care is emotionally and financially burdensome, disproportionally negatively impacting racial and ethnic minorities, rural residents, and lower socioeconomic seniors. Objectives […]
Abstract Introduction The Social Care Network (SCN) is a payor–provider-system integrated social care referral model designed to address historical challenges of scalability and sustainability through […]
Abstract Objectives Gestational trophoblastic disease (GTD) is a rare condition that affects reproductive-age women with excellent clinical outcomes if treated appropriately. The study aims to […]
Abstract Objective: To evaluate the associations between surgeon-patient sex concordance, long-term clinical outcomes and healthcare costs. Background Data: Emerging data suggest surgeon-patient sex concordance may […]
Abstract Knowledge of patterns in COVID-19 deaths by area-level income over time and the mediating role of vaccination in inequality patterns remains limited. We used […]
Abstract Objective: To compare the risk of incident cardiovascular disease (CVD) events following sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). Background: Bariatric surgery is […]
Abstract Introduction Pulmonary lobectomy represents the primary curative treatment for lung cancer in older adults, yet frailty’s impact on critical early postoperative outcomes remains inadequately […]
Abstract Objectives Canadian Armed Forces (CAF) Veterans and former Royal Canadian Mounted Police (RCMP) members (“Veterans/former RCMP members”) may be at increased risk of mental […]
Abstract Traumatic injuries represent a significant public health challenge, affecting millions worldwide annually and necessitating acute pain management that frequently involves the use of opioid […]
ABSTRACT Background People with intellectual or developmental disabilities (IDD) experience breast cancer care inequities relative to those without IDD. Identifying factors associated with receipt of […]
Abstract Introduction Primary care attachment is the formal or informal affiliation with a regular primary care clinician. In countries with near-universal primary care, a physician’s […]
Abstract Background Healthcare expenditures across the clinical trajectory of hepatitis B virus (HBV) infection are inadequately characterized, particularly among immigrants. Our aim is to quantify […]
Abstract Background and Objectives Days alive and at home (DAH) is a validated outcome measure that captures health care transitions between time spent at home […]
Abstract Background and objectives Neurofibromatosis type 1 (NF1) is a multisystemic disease, characterized by cutaneous manifestations and peripheral nerve sheath tumors. Patients also have a […]
Abstract Background To assess population-level trends in use of poly (ADP-ribose) polymerase inhibitors (PARPis) among ovarian cancer patients in the years following initial FDA approvals. […]
Introduction Percutaneous coronary intervention (PCI) is the cornerstone of rapid revascularization in acute myocardial infarction (AMI) [1]. Patients undergoing PCI frequently present with multiple comorbidities, […]
ABSTRACT BACKGROUND Survivors of severe traumatic injury remain at elevated risk of death in the years after injury. Little is known about how long-term mortality […]
Abstract Anti-CD19 chimeric antigen receptor T-cell (CAR-T) immunotherapies have been funded in Canada for relapsed/refractory large B-cell lymphoma (R/R-LBCL) after 2 lines of systemic therapy […]
Graphical abstract
Abstract Background Shingles remains a significant cause of morbidity in people living with HIV despite advances in antiretroviral therapy. The recombinant zoster vaccine (RZV) is […]
Abstract SARS-CoV-2 strained Ontario’s health system, with social determinants of health (SDH) underexplored in cost analyses. We examined COVID-19 attributable healthcare resource use and costs […]
Abstract Purpose To evaluate longitudinal trends and determinants of diabetic retinopathy (DR) screening uptake over 10 years among adults with newly diagnosed diabetes in Ontario, […]
ABSTRACT Anti-CD19 Chimeric Antigen Receptor T-cell (CAR-T) immunotherapies have been funded in Canada for relapsed-refractory large B-cell lymphoma (RR-LBCL) after two lines of systemic therapy […]
Abstract Importance Prior research conducted in private for-profit health care systems has suggested that social determinants of health (SDOH) play a role in adverse postoperative […]
ABSTRACT OBJECTIVE The aim of this study was to investigate the association of home socioeconomic status (SES) with days at home and survival after treatment […]
Abstract Purpose Older and frail adults were under-represented in clinical trials evaluating ICIs, leading to a knowledge gap on their risk of acute care use […]
Abstract Surgical resection is recommended for operable stage I non-small-cell lung cancer (NSCLC), while radiotherapy reserved for inoperable patients. Very comorbid patients may receive no […]
Abstract Background Hepatitis C virus (HCV) infections have increased among younger populations, including pregnant people. While universal screening guidelines have improved case-finding, studies suggest low […]
Abstract Objective To assess whether the five-factor modified frailty index (mFI5) can predict adverse post-operative outcomes in patients with epithelial ovarian cancer (EOC) undergoing interval […]
Abstract Study Design Cohort study. Objectives To determine the prevalence and to identify predictors of prescription opioid use among persons with non-traumatic spinal cord dysfunction […]
Systemic therapies for psoriasis and psoriatic arthritis (PsA) have the potential to cause serious adverse events (SAEs), particularly among older adults (Garcia-Doval et al, 2012; Lavan […]
Abstract Background: Although the use of telehealth has declined since the pandemic, it remains a popular mode of care delivery across the cancer care continuum. […]
Abstract Objective Percutaneous endoscopic gastrostomy (PEG) tube placement is a common gastrointestinal procedure that provides nutrition, fluids, and medications to patients with inadequate oral intake. […]
Background The Barthel Index (BI) measures the level of patient independence in activities of daily living. This review aims to summarize current evidence on the […]
ABSTRACT Aims To examine the association between the widely used social deprivation index, the Child Adjusted Care Need Index, and healthcare centres with a higher […]
Abstract While algorithmic fairness research in healthcare has predominantly focused on disparities in model performance, less attention has been given to the underlying data structures […]
Abstract Background Multimorbidity is the coexistence of two or more chronic diseases, and in older adults is more common which can lead to increased rates […]
Abstract Objectives Breast screening and early detection have positively influenced survival rates for breast cancer. We conducted a randomized-controlled trial involving 7235 eligible members of […]
Abstract Background: Vaccination reduces Coronavirus disease-19 (COVID-19) infection severity. We evaluated COVID-19 vaccine uptake and effectiveness in people with immune mediated inflammatory diseases (pIMIDs) versus […]
ABSTRACT Background Prurigo nodularis patients face a significant burden of comorbidities, necessitating a comprehensive approach to care. We aimed to explore the association between prurigo […]
Structured Abstract Introduction Foster care admissions are highly traumatic for children and their families, often causing serious adverse outcomes. We seek to assess the viability […]
ABSTRACT OBJECTIVES To assess the risk of concurrent emergency department use (Co-ED) among women with a preexisting disability and their infants. METHODS This population-based cohort […]
Background The Health Equity Payment (HEP) scheme was developed by population health leads from NHS Leicester, Leicestershire and Rutland (LLR) Integrated Care Board (ICB), intended […]
Abstract Depression, a prevalent health condition, substantially impacts both socioeconomic outcomes and individual wellbeing. Despite the availability of diagnostic tools, existing approaches for identifying depression […]
Abstract Background Capitation payments account for approximately half of core funding for General Practitioner (GP) practices in England, allocated via the Global Sum Allocation (‘Carr-Hill’) […]
Abstract Background: The long-term impacts of traumatic brain injury (TBI) in older adults are not well known. Our objective was to describe the association between […]
ABSTRACT Background This study examined death from breast cancer and death from other causes among women with Stage 1 and 2 Her2-positive and triple-negative breast […]
Abstract Introduction More health systems are implementing strategies to understand and address patient social health, also known as social health integration. We examine the impact […]
Abstract Background: Primary care attachment, defined as a patient’s formal or informal affiliation with a regular primary care provider, is a cornerstone of many healthcare […]
Abstract Purpose Sustained virologic response (SVR) is a validated surrogate marker for successful hepatitis C virus (HCV) treatment. Historically, interferon-based therapies, the standard of care […]
Abstract Purpose This study aimed to evaluate the impact of patient demographics, surgeon volume, and hospital type on composite outcomes, infection, and revision following surgery […]
Abstract Background: Multimorbidity is the co-occurrence of two or more chronic conditions in one person. Providing quality, patient-centered care requires understanding multimorbidity. Our objective was […]
Abstract Background The COVID-19 pandemic exacerbated health inequities, particularly among individuals with opioid use disorder (OUD). Disparities in vaccine uptake among people with OUD remain […]
ABSTRACT Introduction Over the last 20 years, the Canadian province of Ontario implemented several new models of primary care focusing on changes to physician remuneration, […]
To deliver on the promise of high-quality, value-based care for our patients in the context of workforce shortages and an aging population, risk stratification is […]
Summary Ibrutinib is metabolized by cytochrome P450 3A (CYP3A) and poses challenges with drug interactions. We conducted a population-based cohort study of Ontario residents aged […]
Abstract Background High-deductible health plan (HDHP) members face relatively high out-of-pocket (OOP) costs for urgent care, high-acuity care, and secondary prevention. These costs could affect […]
Abstract Background and Aim: In 2021, healthcare expenditure in Italy represented 7.3% of the national gross domestic product, with approximately 80% attributed to the management […]
Abstract Objectives To quantify potentially inappropriate prescribing (PIP) and assess the association between patient characteristics and PIP using previously coded STOPP-START and Beers criteria in […]
Abstract Background This study examined the impact of frailty on in-hospital outcomes in patients undergoing surgical stabilization of multiple rib fractures and flail chest (SSRF). […]
Abstract Objective: Determine whether a Medicare 7-day limit on initial opioid prescriptions (effective January 1, 2019) was associated with reductions in duration, dosage, and subsequent […]
Abstract Background: COPD risk profiles have been described in populations comprised of or including older adults, leaving factors associated with COPD in younger adults overlooked. […]
Abstract OBJECTIVE: To assess trends in insulin out-of-pocket (OOP) costs, use, and disparities among commercially insured patients from 2008 to 2021. STUDY DESIGN: Retrospective time […]
ABSTRACT Objective: To describe trends in employer preventive drug list (PDL) offerings and associations of employer PDL offerings with employer and workforce characteristics. Study Design: […]
Abstract Background Respiratory syncytial virus (RSV) causes substantial morbidity and mortality among adults. Given recent RSV vaccine authorizations, data on groups at highest risk are […]
Abstract Objective Determine relationship between frailty and hospital mortality, length of stay, cost, and medical and surgical complications in Zenker diverticulum surgery. Study Design Retrospective […]
Abstract Individuals with Attention-Deficit/Hyperactivity Disorder (ADHD) experienced worsening symptoms during the COVID-19 pandemic resulting in increased demand for healthcare services. However, it is unclear how […]
Abstract Background Frailty, marked by reduced physiological resilience, is associated with adverse outcomes in patients undergoing various cardiovascular procedures. The rising incidence of cardiac implantable […]
Abstract Introduction Survivors of childhood and adolescent cancers are at increased risk for late effects. Few studies have investigated if this translates into increased healthcare […]
Abstract Background and Objectives Headache syndromes are highly prevalent, disabling, and costly. Our goals were to (1) describe headache care delivery and costs in a […]
Abstract Background The quality-adjusted life year (QALY) is widely used to measure health outcome that combines the length of life and health-related quality of life […]
Abstract Background Hepatitis C virus (HCV) infection is associated with reduced quality of life and health utility. It is unclear whether this is primarily due […]
Abstract Objectives The relationship between frailty and both short- and long-term outcomes remains underexplored in gynecologic oncology (GO). We sought to evaluate the association of […]
Abstract Background There are few studies describing health services use and longer-term survival in older adults with major injuries. Our objectives were to characterize the […]
Abstract Background: One of the critical challenges with capitation payment to primary care providers is ensuring that the fixed payments are equitable and adjusted for […]
Abstract Background Population risk stratification (RS) tools have been proposed to tailor interventions, prioritize resources, and proactively manage high-risk individuals with chronic diseases in primary […]
Abstract OBJECTIVE: Health care networks are increasingly turning to programs that provide office-based care coordination to high-cost, high-need patients to control preventable health care costs. […]
Abstract Background Provider burnout due to workload is a significant concern in primary care settings. Workload for primary care providers encompasses both scheduled visit care […]
Abstract Hip fractures have life-altering consequences. Individuals with schizophrenia may experience a higher likelihood of hip fractures, worse postfracture outcomes, and suboptimal care. This thesis […]
Abstract Survivors of childhood and adolescent cancers are at increased risk for late effects including subsequent cancer, cardiotoxicities, and poor psychosocial health. Few studies have […]
Abstract Telemedicine in primary health care is expected to address many of the issues currently challenging service delivery. However, the impact and effect will depend […]
Abstract Purpose To address the extent to which Federally Qualified Health Centers (FQHCs) and independent and provider-based Rural Health Clinics (RHCs) were using telehealth prior […]
Abstract Under the current Medicare Advantage (MA) risk-adjustment system, plans are incentivized to report diagnosis codes on enrollees’ medical claims reflecting additional and more severe […]
Abstract Background: A growing number of US states are implementing programs to address the social needs (SNs) of their Medicaid populations through managed care contracts. […]
Abstract Background The Adjusted Clinical Groups (ACG) System is a validated electronic risk stratification system. However, there is a lack of studies on the association […]
Abstract Purpose It is difficult to reduce cost and improve quality without knowledge pertaining to the distribution of expenses in the population in question. We […]
Abstract Background Twenty-five states have implemented insulin out-of-pocket (OOP) cost caps, but their effectiveness is uncertain. Objective To examine the effect of state insulin OOP […]
Abstract Introduction Increased attention has been given to multimorbidity. This phenomenon often has been explored through associations between diseases based on the frequency of combinations […]
