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Percutaneous coronary intervention (PCI) is the cornerstone of rapid revascularization in acute myocardial infarction (AMI) [1]. Patients undergoing PCI frequently present with multiple comorbidities, and frailty – characterized by increased biological vulnerability, impaired multisystem function, and reduced physiological reserve – further predisposes to adverse clinical events [2]. However, the extent to which frailty influences prognosis after PCI for AMI is not clearly delineated with variable data. This study evaluated outcomes in frail patients following PCI for AMI using a large, nationally representative US cohort.