Evaluating patient adherence to antidepressant therapy among uninsured working adults diagnosed with major depression: results of the Texas Demonstration to Maintain Independence and Employment study

Published: September 1, 2012
Category: Bibliography > Papers
Authors: Bohman TM, Christensen K, Nwokeji ED, Ostermeyer B, Reed BC, Spence RR, Stoner D, Wallisch L
Countries: United States
Language: null
Types: Population Health
Settings: Government, PCP

Adm Policy Ment Health 39:374-382.

Addiction Research Institute, University of Texas at Austin, Austin, TX, USA

This study examined antidepressant adherence and persistence among uninsured working adults diagnosed with major depression enrolled in the Texas Demonstration to Maintain Independence and Employment (DMIE) program. Antidepressant adherence was measured between intervention and control cohorts using proportion of days covered (PDC) during a 365-day observation period. Persistence examined duration of time from drug initiation to discontinuation based on a ≥35-day refill supply gap. Older, non-minority patients with higher education were more adherent or persistent to antidepressant therapy. Adjusting for covariates, results showed no significant difference in PDC at the end of 12-months between intervention and control participants (b = .07, P = .054, semi-partial η (2) = .02). Exploratory analysis found subgroup differences in PDC among the study recruitment cohorts. No significant difference between intervention and control groups was found in persistence between the groups. Follow-up investigation is planned to assess the longer term impact of the DMIE program on antidepressant adherence and persistence.

PMID: 21553144

Targeted Program,Medications,Population Markers,United States,Adult,Age Factors,Cohort Studies,Educational Status,Employment,Gender,Medically Uninsured,Middle Aged,Poverty,Texas

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