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papers

Adverse events recorded in English primary care: observational study using the General Practice Research Database

Published: August 1, 2013
Category: Papers
Authors: Aylin P, Bottle A, Majeed A, Tsang C
Country: United Kingdom
Language: null
Type: Care Management
Settings: Government, Hospital

Br J Gen Pract 63:534-542.

Department of Primary Care and Public Health (DPCPH), Imperial College London, London, UK

BACKGROUND: More accurate and recent estimates of adverse events in primary care are necessary to assign resources for improvement of patient safety, while predictors must be identified to ameliorate patient risk.

AIM: To determine the incidence of recorded iatrogenic harm in general practice and identify risk factors for these adverse events.

DESIGN AND SETTING: Cross-sectional sample of 74 763 patients at 457 English general practices between 1 January 1999 and 31 December 2008, obtained from the General Practice Research Database

METHOD: Patient age at study entry, sex, ethnicity, deprivation, practice region, duration registered at practice, continuity of care, comorbidities, and health service use were extracted from the data. Adverse events were defined by Read Codes for complications of care (Chapters S, T, and U). Crude and adjusted analyses were performed by Poisson regression, using generalised estimating equations.

RESULTS: The incidence was 6.0 adverse events per 1000 person-years (95% confidence interval [CI] = 5.74 to 6.27), equivalent to eight adverse events per 10 000 consultations (n = 2 540 877). After adjustment, patients aged 65-84 years (risk ratio [RR] = 5.62, 95% CI = 4.58 to 6.91; P0.001), with the most consultations (RR = 2.14, 95% CI = 1.60 to 2.86; P0.001), five or more emergency admissions (RR = 2.08, 95% CI = 1.66 to .60; P0.001), or the most diseases according to expanded diagnosis clusters (RR = .46, 95% CI = 5.68 to 12.6; P0.001) were at geater risk of adverse events. Patients registered at their practice for the longest perids of time were less at risk of an adverse event (RR = 0.40, 95% CI = 0.35 to 0.47; P<0.001).

CONCLUSION: The low incidence of recorded adverse events is comparable with other studies. Temporal sequencing of risk factors and case ascertainment would benefit from data triangulation. Future studies may explore whether first adverse events predict future incidents.

PMID: 23972194

PMCID: PMC3722830

Age,Gender,Population Markers,Predictive Risk Modeling,Co-morbidity,United Kingdom,Adolescent,Adult,80 and over,Child,Preschool,England/epidemiology,Epidemiologic Methods

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